Reversal of factor Xa inhibitors
Many people prefer the new blood anticoagulants like Xarelto to the old warfarin, because they don’t require continuous monitoring. Their one sticking point was that there was no way to reverse their effect in the ER, in case of trauma. That is about to change. Portola Pharmaceuticals is applying for approval of andexanet alfa, that effectively reverses the effect of factor Xa inhibitors within minutes.